H Trobisch

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BACKGROUND AND OBJECTIVES Pooled nucleic acid amplification techniques (NAT) and donor screening for anti-hepatitis C virus (HCV) have reduced the diagnostic window period of HCV infection in the blood donor population from about 12 to 1 or 2 weeks. During that time, HCV RNA is hardly detectable by pooled or individual donation NAT. Here we describe a case(More)
HISTORY AND ADMISSION FINDINGS A 40-year-old woman was admitted to the emergency room because of severe angina pectoris and dyspnoe at rest. She developed ventricular fibrillation a few minutes later from which she had to be resuscitated . After intubation and controlled ventilation immediate angiocardiography was performed while she was still in(More)
BACKGROUND AND OBJECTIVES The aim of this study was to evaluate the quality of leucocyte-depleted plasma produced from leucocyte-depleted whole blood, stored for different periods of times before filtration through polyurethane filters. MATERIALS AND METHODS Whole blood was collected, from 48 voluntary donors, into quadruple blood bag sets with integrated(More)
Antithrombin III, the most important inhibitor of activated coagulation factors (IIa, IXa, Xa, XIa, XIIa) was isolated from human plasma by affinity chromatography. The biochemical characterization of this highly purified inhibitor showed, that is was uniform by means of HPLC and PAA gradient gel electrophoresis. The molecular weight was determined to 70000(More)
Forty-four patients with haemophilia A or von Willebrand-Jürgens syndrome were followed for three years. They received about 28 000 cryoprecipitate produced in the author's laboratories, without a single case of hepatitis B. There were seven among these patients who had no antibodies against surface antigen: they had received a total of 2533(More)
Factor XIII was determined by enzymatic and immunochemical methods in 3 patients with congenital factor XIII deficiency. Factor XIII activity measured by trans-glutaminase assay was below 1% of normal value in each of these cases. Immunelectrophoresis determination revealed the absence of the functionally active subunit A, whereas subunit S was only(More)
Two patients had neovascularizations, bleeding and enclosed vessels or pigmented foci on the retina. The analysis of the hemoglobin showed a raised HbA2 fraction, indicating that they could be considered heterozygous gene carriers of beta-thalassemia. An electrophoretic-spectrophotometric method of determining the hematologic changes is described by means(More)