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We formulate a dynamic mathematical model that describes the interaction of the immune system with the human immunodeficiency virus (HIV) and that permits drug "cocktail " therapies. We derive HIV therapeutic strategies by formulating and analyzing an optimal control problem using two types of dynamic treatments representing reverse transcriptase (RT) in(More)
State-dependent Riccati equation (SDRE) techniques are rapidly emerging as general design and synthesis methods of nonlinear feedback controllers and estimators for a broad class of nonlinear regulator problems. In essence, the SDRE approach involves mimicking standard linear quadratic regulator (LQR) formulation for linear systems. In particular, the(More)
BACKGROUND Dengue is a major public health problem in tropical and subtropical countries. Rapid and easy diagnosis of dengue can assist patient triage and care-management. The detection of DENV NS1 on rapid lateral flow tests offers a fast route to a presumptive dengue diagnosis but careful evaluations are urgently needed as more and more people use them.(More)
BACKGROUND There is currently no licensed antiviral drug for treatment of dengue. Chloroquine (CQ) inhibits the replication of dengue virus (DENV) in vitro. METHODS AND FINDINGS A double-blind, randomized, placebo-controlled trial of CQ in 307 adults hospitalized for suspected DENV infection was conducted at the Hospital for Tropical Diseases (Ho Chi Minh(More)
We propose the use of proper orthogonal decomposition (POD) techniques as a reduced basis method for computation of feedback controls and compensators in a high pressure chemical vapor deposition (HPCVD) reactor. In this paper, we present a proof-of-concept computational implementation of this method with a simpliied growth example for III-V layers in which(More)
LQG compensator control of transverse vibrations was implemented on an aluminum can-tilevered beam in a "smart structure" paradigm. The beam was mounted with two self-sensing, self-actuating piezoceramic patches. The Euler-Bernoulli beam equation was discretized via a Galerkin type approximation (referred to as the full order model). To reduce the size of(More)
BACKGROUND Dengue is a major public health problem in tropical and subtropical countries. Exploring the relationships between virological features of infection with patient immune status and outcome may help to identify predictors of disease severity and enable rational therapeutic strategies. METHODS Clinical features, antibody responses and virological(More)