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Substantial plasticity of the mature mammalian somatosensory cortex was demonstrated after deprivation of sensory input produced by amputation or somatosensory deafferentation. Following transection of the median nerve, adult owl and squirrel monkeys exhibit extensive reorganization in the cortical representation of the hand in areas 3b and 1. In the(More)
We propose a histopathological classification system for hippocampal cell loss in patients suffering from mesial temporal lobe epilepsies (MTLE). One hundred and seventy-eight surgically resected specimens were microscopically examined with respect to neuronal cell loss in hippocampal subfields CA1-CA4 and dentate gyrus. Five distinct patterns were(More)
Electrical stimulation of the vagus nerve (VNS) is a new method for the treatment of patients with medically intractable epilepsy. Sixteen patients, ten of whom participated in a larger multicenter double-blind trial on the efficacy of VNS in epilepsy, and six who participated in pilot studies, consented to participate in the present study. Ten patients(More)
We investigated two important means for improving source reconstruction in presurgical epilepsy diagnosis. The first investigation is about the optimal choice of the number of epileptic spikes in averaging to (1) sufficiently reduce the noise bias for an accurate determination of the center of gravity of the epileptic activity and (2) still get an(More)
BACKGROUND Cavernous haemangiomas (cavernomas) are benign vascular malformations which can be found at any region within the central nervous system. Epilepsy is the most frequent manifestation of this malformation. Magnetic resonance imaging (MRI) used for the diagnostic evaluation of symptomatic seizures is a sensitive and specific method for the detection(More)
PURPOSE Autonomic seizures in temporal lobe epilepsies associated with "cold shivers and goose bumps" as a principal ictal sign or aura have only rarely been studied. METHODS Sixteen patients with autonomic auras [cold shivers or cold sweats (n=11), goose bumps (n=4), one patient showed both ictal signs] were analyzed. RESULTS Lesions were detected in(More)
Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial number of patients remain without(More)
PURPOSE In this study 30 patients with symptomatic epilepsy caused by cavernomas were investigated in a postoperative follow up study to assess predictors for postoperative outcome with respect to indications, time and approach of surgery. METHODS Thirty patients with cavernomas refractory to medical treatment were scheduled for surgery based on the(More)
These guidelines apply to patients whose seizures have not been controlled by antiepileptic drugs and who are being evaluated for possible surgery. They are supplemental to the general ''Recommendations for Neuroimaging of Patients with Epilepsy. " 2. GOALS In individual patients undergoing presurgical evalua-a. Delineation of structural and functional(More)