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The immune function of peripheral mononuclear cells (MNC) in patients with endemic arsenic-induced Bowen's disease (BD) was investigated. Many cytokines and immune-related factors were determined in the present study. Interleukin-1beta and TNF-alpha production was used as an indicator of monocyte/macrophage function. II-2 and sIL-2R production was used as(More)
Objective: To investigate whether interleukin-13 (IL-13) can affect arachidonic acid metabolism and phagocytic activity of normal human polymorphonuclear neutrophils (PMN).¶Methods: Normal human PMN (1 × 106 cells/ml) were incubated with different concentrations of IL-13 (0.1–10 ng/ml) for a variety of times (30–120 min). Phagocytosis and intracellular(More)
Objective and Design: To determine whether anti-double stranded DNA antibody (anti-dsDNA) can affect the synthesis of eicosanoids and cytokines in rat glomerular mesangial cells (RMC).¶Materials or Subjects: Glomerular mesangial cells were isolated and subcultured from Sprague-Dawley rats. Monoclonal anti-dsDNA (12B3 clone) was derived from autoimmune(More)
Epidermal keratinocytes contain the β-adrenergic adenylate cyclase system, which when activated causes an accumulation of intracellular cyclic AMP through stimulatory guanosine 5-triphosphate (GTP) binding proteins [1]. Adrenergic receptors are responsible for selective recognition and binding of catecholamines, affecting epidermal cell proliferation and(More)
The Qinghai-Tibet railway is the highest railway in the world. The operational conditions of this railway are very harsh, such as occurrence of earthquake, potential melting of frozen soil, and severely cold and thin air. Real time monitoring the deformation of the railway system for maintaining safe operation has posed a big challenge. Extensive document(More)
Epidemiological studies have revealed that exposure to arsenic (As) induces skin cancer [1]. As-induced skin cancers are usually found on non-sun-exposed areas [2]. Ultraviolet B (UVB) irradiation has been used in the treatment of hyperproliferative dermatoses, such as psoriasis [3] and cutaneous T-cell lymphoma [4]. Furthermore, UVB irradiation exerts an(More)
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