H. S. Naveen Kumar

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A new series of isonicotinoyl hydrazone derivatives (3a–3o) have been synthesized, characterized and evaluated for in vitro antimycobacterial activity against M. tuberculosis H37Rv and two clinical isolates using tetrazolium microplate assay (TEMA). Some of these compounds showed moderate to good antimycobacterial activity at micro molar concentrations.(More)
Enoyl–acyl carrier protein reductase (InhA) is an important enzyme for the biosynthesis of mycolic acids which are central constituents of the mycobacterium cell wall. In the present study, we synthesized, characterized hydrophobic N-acylated isonicotinic acid hydrazide derivatives (2a–2m) as potential enoyl–acyl carrier protein reductase (InhA) inhibitors(More)
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