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From studies on sympathetically innervated peripheral tissues it is well known that both neuronal and non-neuronal transport systems contribute to the inactivation of released monoamine transmitters. The close proximity between synapses and glia cell processes in the CNS leads to the so far unresolved question whether non-neuronal transporters are involved(More)
Noradrenaline, the neurotransmitter of the sympathetic nervous system, is removed from the extracellular space by both neuronal and extraneuronal transport mechanisms. In the past, further investigation of the extraneuronal type of noradrenaline transporter was severely hampered by the lack of potent inhibitors. Here, we describe the synthesis of various(More)
Corticosterone-sensitive extraneuronal transport (uptake2) and metabolism of noradrenaline was investigated in the clonal human Caki-1 cell line. Caki-1 cells are the first experimental system for uptake2 which is based on a tissue culture technique. Previous experiments with Caki-1 cells opened the possibility of a close relationship between uptake2 and(More)
The neurotransmitter noradrenaline is inactivated by active transport out of the synaptic cleft--either back into the adrenergic neuron or into extraneuronal cells. Transport studies on isolated cells provide many advantages. However, an experimental model for the extraneuronal uptake of noradrenaline which is based on a clonal cell line was not known until(More)
The gravitational instability of inhomogeneities in the expanding universe is studied by the relativistic second-order approximation. Using the tetrad formalism we consider irrotational dust universes and get equations very similar to those given in the Lagrangian perturbation theory in Newtonian cosmology. Neglecting the cosmological constant and assuming(More)
Noradrenaline is taken up in noradrenergic neurones via a desipramine-sensitive transport system (uptake1). There are reports which describe the activity of uptake1 being increased by extracellular ATP and ATP gamma S. This was attributed to a protein kinase-mediated mechanism. We reevaluated this phenomenon since a modulation of uptake1 by extracellular(More)
The combination of hypoxia plus glucose deprivation or of hypoxia plus lactate induces carrier-mediated outward transport of 3H-noradrenaline in the rat vas deferens. Lactate efflux is higher from atria than from vas deferens. Hence, the much lower contribution by outward transport to the spontaneous efflux of 3H-noradrenaline in vas deferens than atria is(More)
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