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The influence of acetylsalicylic acid (ASA) and naproxen on growing bones was studied. Young male rats were used. The drugs were administered via gastric gavage twice a day for 9 or 18 days. Drug doses giving serum concentrations corresponding to ordinary anti-inflammatory steady-state levels in humans were used. There was a drug-related influence on the(More)
The effects of acetylsalicylic acid (ASA) on bone metabolism have been studied in a bone transplantation model using radioisotopic and biochemical parameters. Isografts (femora) from infant inbred rats, extensively prelabeled with collagen and mineral-tracing radioisotopes, were transplanted to muscle pouches in young male rats. Bones from the opposite side(More)
Antigen-extracted, autolyzed, demineralized bone matrix and bone matrix combined with isogeneic bone marrow (i.e., a composite graft) were placed in the musculature of young male rats. The influence of acetylsalicylic acid (ASA) on the osteogenic potential of these bone-inducing materials was studied during an 18-day period. ASA (150mg/kg/12h) was used to(More)
The influence of acetylsalicylic acid (ASA) (150mg/kg/12h) and naproxen (20mg/kg/12h) on bone metabolism in young male rats has been studied. The doses were chosen to provide serum concentrations comparable with ordinary anti-inflammatory steady-state levels in humans. After the rats had been prelabeled with collagen- and mineral-tracing radioisotopes the(More)
Titanium and TCP-coated implants were compared after insertion in the canine iliac crest. Observation time was 14 wk. Evaluation included pull-out tests, energy dispersive X-ray analysis, and histologic examination of in situ, undemineralized implants. The TCP-coated implants were more firmly attached to bone than were the titanium implants. The(More)
The influence of acetylsalicylic acid (ASA) and naproxen on the biochemical properties of intact growing femora in young male rats was studied. The medication periods were 9 and 18 days. At an ASA dose of 150 mg/kg/12 h the rate of collagen synthesis and the rate of mineral incorporation decreased and were impaired by about 10% compared with controls after(More)
Acetylsalicylic acid, ASA (150 mg/kg/12 h), and naproxen (20 mg/kg/12 h) were administered to young male rats for 9 and 18 days. The doses were set to provide serum concentrations comparable with anti-inflammatory steady state levels in humans. Mechanical tests were performed on skin from the back of the rats. The drugs did not affect the tensile strength(More)
The influence of salmon calcitonin on the growth of teeth and alveolar bone, and on the healing of alveolar sockets has been studied in young male rats. The experimental animals received daily injections of salmon calcitonin 0.5 MRC-U/kg body weight, whereas the control group received the vehicle. The rats were sacrificed at 14 and 28 days after the tooth(More)
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