Learn More
Human papillomaviruses (HPV) have been implicated in the development of non-melanoma skin cancer (NMSC). HPV types 5 and 8 are strongly associated with NMSC in patients with the inherited disease Epidermodysplasia verruciformis (Ev). In these patients tumours arise predominantly on sun-exposed skin and consistently harbour HPV DNAs. To determine whether(More)
Peptides presented on major histocompatibility complex (MHC) class I molecules are generated via cytosolic proteolysis. However, the nature of the endogenous peptide precursors and the intracellular processing steps preceding protein degradation remain poorly defined. Here, we assessed whether ubiquitination is an essential signal for proteasomal cleavage(More)
The Murchison Widefield Array (MWA) is a next-generation radio telescope currently under construction in the remote Western Australia Outback. Raw data will be generated continuously at 5 GiB s−1, grouped into 8 s cadences. This high throughput motivates the development of on-site, real time processing and reduction in preference to archiving, transport and(More)
The regulatory regions of the human papillomaviruses (HPVs) 9, 17, 20, and 36 were mapped, sequenced, and aligned. They revealed an arrangement of putative protein binding sites specific for the epidermodysplasia verruciformis associated HPVs. Three subgroups could be differentiated.
M. Abdelazizm Mohamed P. Acevedo D. Albach E. Albertini R. Alia G. A. Allen L. Aona M. Appelhans B. Appezzato S. Arndt E. Austen J. Bachelier H. Ballard A. M. Banaei Moghaddam K. Bardy J. Batley A. Baumel M. Beilstein A. Bello V. Bittrich S. Blackmore F. Blattner M. Bog T. Brown S. Bruun-Lund W. Buck P. Bures M. T. Buril S. Buzato J. Byng L. Carlon R.(More)
This article addresses the question of when a trial master file (TMF) can be considered sufficiently accurate and complete: What attributes does the TMF need to have so that a clinical trial can be adequately reconstructed from documented data and procedures? Clinical trial sponsors face significant challenges in assembling the TMF, especially when dealing(More)
Human papillomavirus type 8 (HPV8) poses a high risk for malignant conversion of skin lesions in patients with Epidermodysplasia verruciformis (Ev). Its oncogene promoter P175 contains the conserved sequence motifs CCAAC, M29, and an A/T-rich region, which are common in many Ev-associated viruses. In human keratinocytes P175 shows very weak activity. We(More)
  • 1