H P Meissner

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The effect of a "square wave" stimulation with glucose or glibenclamide on the electrical activity of beta-cells has been studied with microelectrode techniques in isolated perifused mouse islets. While glucose evoked a burst activity with periodic oscillations of the membrane potential between two levels, glibenclamide produced a constant depolarization(More)
1. The electrical activity of beta-cells is characterized by a regular burst pattern. 2. The bursts occur in a potential range which is not dependent on external glucose concentration. However, there is a clear dose-response relationship between spike frequency or plateau duration and the glucose concentration. 3. There is a striking biphasic pattern of the(More)
The effects of forskolin, an activator of adenylate cyclase, on the membrane potential of pancreatic B cells have been studied with microelectrodes. Forskolin (5 microM) did not affect the stable resting membrane potential (3 mM glucose). In the presence of 10 mM glucose, forskolin lengthened the slow waves with superimposed spikes and shortened the(More)
The ionic basis of the glucose-induced membrane potential changes in pancreatic B-cells was investigated. The results suggest that the initial depolarization of the membrane in response to a stimulation with glucose is due to a decrease of the K permeability. This depolarization seems to open a voltage-dependent Ca-channel and thereby an additional(More)
The membrane potential of mouse pancreatic beta-cells was measured with microelectrodes. In the resting cell (3 mM D-glucose), the membrane potential was -63 +/- 3 mV (mean +/- S.E. for four experiments). In the presence of 3 mM D-glucose, total Cl- substitution by isethionate induced a depolarization by 3-4 mV, and readmission of Cl- induced a(More)
The general purpose of the magnetohydrodynamic research is to explore interaction phenomena in those situations in which the fluid can be considered to be predominantly a continuum. This includes a wide range of phenomena, from the flow of liquid metals through magnetic fields to the propagation of hydromagnetic shock waves. At the present time, we are(More)
  • S C Brown, G Bekefi, Elinor K Charney, V H Yngve, J S Barlow, W A Clark +3 others
  • 2009
On the semantical interpretation of linguistic entities that function structurally E. S. Klima, Structure at the lexical level and its implications for transfer grammar G. H. Matthews, Analysis by synthesis of sentences of natural languages
An electric field applied perpendicular to a plane conducting interface of a static fluid can produce an instability. As a direct consequence of the static condition of the unperturbed interface, the instability is nonconvective.2 If the fluid is in motion with a constant velocity V o , there is a velocity that is such that the instability manifests itself(More)
  • Esther Eun, Kyu Kim, Jefferson W Tester, H P Meissner, David H Marks, Morton +17 others
  • 2001
ACKNOWLEDGEMENTS I would first like to express my gratitude to my advisors, Professor Jefferson Tester and Howard Herzog of the MIT Energy Laboratory, for their unwavering support, guidance, and constructive comments on this thesis. They have been two of the most patient and understanding advisors I could ever hope for, as obstacle after obstacle came up(More)