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OBJECTIVE The association between uric acid and cardiovascular disease is poorly studied. We undertook this study to assess whether uric acid level predicts clinical outcome in patients with stable coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI). MATERIALS/METHODS This study included 8149 patients with stable CAD who(More)
BACKGROUND The optimal uric acid (UA) level associated with the lowest mortality and the strength of association between UA and mortality in various subgroups of patients with coronary artery disease (CAD) are unknown. MATERIALS AND METHODS This study included 13 273 patients with angiographic confirmation of CAD and UA measurements available. The primary(More)
OBJECTIVE The objective of this study was to investigate the effect of renal impairment on the pharmacokinetics of the selective beta1-receptor antagonist talinolol. METHODS Pharmacokinetic data were obtained in 12 healthy volunteers, 12 patients with renal impairment and 8 patients with terminal renal insufficiency after the oral administration of 100 mg(More)
The impact of coronary atherosclerotic burden on prognosis and presentation of patients with coronary artery disease (CAD) is unknown. We investigated the association of coronary atherosclerotic burden with clinical outcome and presentation as unstable angina in patients with CAD. This study included 10,647 patients with stable (n = 8,149) and unstable (n =(More)
The electrical potential difference (PD) of gastric mucosa was measured under direct endoscopic visualization in 39 patients. Seventy-six observations were made, 39 in fundic mucosa and 37 in the antral region. Biopsies taken from these areas allowed the identification of a control group and a gastritis group. The PD measurements of the control group were(More)
The association between uric acid and cardiovascular disease is incompletely understood. In particular, the prognostic value of uric acid in patients with acute coronary syndromes who undergo percutaneous coronary intervention has not been studied. This study included 5,124 patients with acute coronary syndromes who underwent percutaneous coronary(More)
BACKGROUND While most anaesthetics are known to suppress immune reactions, data from experimental studies indicate the enhancement of reactivity to inflammatory stimulators under xenon treatment. We investigated the effect of xenon anaesthesia on leucocyte function in surgical patients. METHODS We performed a subgroup analysis of subjects undergoing xenon(More)
Studies investigating the prognostic role of UA (uric acid) in patients with Type 2 diabetes mellitus have given conflicting findings. We undertook the present study to assess the association between UA and outcome in patients with Type 2 diabetes mellitus and CAD (coronary artery disease). The study included 3705 patients with diabetes mellitus and(More)