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I N the course of quantitative studies of experimental blood dyscrasias in laboratory mice, two inbred strains of mice were studied to establish normal values in young adult females. The data include mean and standard deviations of leucocyte count, differential count, erythrocyte count, hemoglobin and hematocrit determinations, and reticulocyte count of(More)
The livers of both baboons and rhesus monkeys fed a high fat, high cholesterol diet secreted very low density lipoproteins (VLDL) that were enriched in cholesteryl ester and apoe as compared to VLDL secreted by the livers of chow-fed animals. Stimulation of macrophage cholesterol esterification by the experimental VLDL was compared to that produced by the(More)
The relationship between macrophage cholesterol content and apolipoprotein E (apoE) synthesis was studied in mouse peritoneal macrophages. Incubations in acetylated low density lipoprotein led to a concentration-dependent increase in macrophage free and esterified cholesterol content and apoE synthesis. Enhanced apoE production reflected increased apoE mRNA(More)
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