H Markus Weiss

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AIMS To determine blood binding parameters of imatinib and its metabolite CGP74588 in humans and non-human species. METHODS The blood distribution and protein binding of imatinib and CGP74588 were(More)
Over the last few years, Pichia pastoris has been developed into a powerful expression system for a multitude of foreign genes. Here, we demonstrate that the P. pastoris expression system has similar(More)
PKI166, a specific inhibitor of the tyrosine kinase activity of two epidermal growth factor receptors, was under development for the treatment of cancer. In preclinical studies PKI166 was mainly(More)