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Mice treated with apomorphine tend to adopt a vertical position in a stereotyped manner. A quantal evaluation of this behaviour, taking into account its frequency and duration, leads to a biphasic dose-response curve that reveals opposite actions of the dopamine agonist.
Apomorphine in low dosage (0.3 mg/kg) inhibits climbing behavior, a stereotyped motor activity, in mice. Pretreatment with apomorphine in low doses (0.125 or 0.25 mg/kg) or with piribedil (25 mg/kg), a weak dopamine agonist, results in a less marked inhibitory effect of the test dose of apomorphine. Apomorphine in low dosage or piribedil are also able to… (More)
In the mouse 'behavioral despair' test the immobility time was shortened by [D-Ala2,Met5]enkephalin at doses which did not modify locomotor activity. Similarly, the inhibitors of the enzymes degrading enkephalins, thiorphan and/or bestatin were effective. Their effect was antagonized by naloxone. We conclude that endogenous enkephalins are implicated in the… (More)