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Topoisomerase I (Topo I) is overexpressed in cancer colon tissues compared with normal colon tissues. Several anti-Topo I inhibitors are already successfully used in the clinic. We illustrate here the antiproliferative activity of a new class of Topo I inhibitors, i.e., E-ring-modified camptothecins with enhanced lactone stability (L. Lesueur-Ginot et al.,(More)
Differences in efficacy found in animals between recombinant forms of erythropoietin will not necessarily translate into differences in humans Sir In your supplemental issue for volume 84, dated April 2001, Egrie and Browne (2001) reported a compilation of studies on the char-acterisation of novel erythropoiesis stimulating protein (NESP). NESP is a mutated(More)
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