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This paper describes the application of a new real-time dam optimization technology to the Orange-Fish-Sundays River Basin in South Africa. In a robust and resilient setting, the system integrates real-time data, a novel hydrological and hydraulic forecasting model and a dedicated computing solution. An efficient data assimilation technique is used to(More)
BACKGROUND Recent studies have found vitamin D (25-OHD) deficiency and insufficiency to be common among patients with COPD. Serum level of 25-OHD seems to correlate to pulmonary function, COPD disease staging, and increased susceptibility to respiratory infections. We wanted to investigate whether vitamin D deficiency or insufficiency was associated with(More)
The objective was to assess whether the concurrent use of tramadol and vitamin K antagonists (VKAs) leads to an increased risk of excessive anticoagulation. The study was designed as a case–control study, nested within users of VKA and with tramadol use as our main exposure. We used conditional logistic regression to control for potential confounders.(More)
BACKGROUND Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffering from inflammatory lung disease, but its prognostic value in patients with COPD remains unknown. We investigated whether high plasma(More)
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