H. Lovell Hoffman

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Acute disseminated encephalomyelitis, with its histological appearance of perivenous demyelination and cellular infiltration, has been recognized for more than 30 years, but opinions regarding its aetiology have changed considerably during this time. At first it was thought that a direct virus infection of the central nervous system was responsible. Later,(More)
The risk of opportunistic infections is greatly increased in patients who are immunocompromised due to AIDS, cancer chemotherapy and organ or bone marrow transplantation. Candida albicans is often associated with serious systemic fungal infections, however other Candida species such as Candida krusei, Candida tropicalis and Candida glabrata, as well as(More)
Voriconazole is a new triazole antifungal agent structurally related to fluconazole, but with improved potency and spectrum of activity. Voriconazole has good in vitro activity against Candida species, Cryptococcus neoformans, Aspergillus spp. and other mould spp. Initial clinical studies and case reports demonstrate efficacy with voriconazole against(More)