H. Leigh Johnson

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Methadone maintenance has been the treatment of choice for heroin addiction for several years. The prenatal and early neonatal effects have been described in several reports (Kandall et al. 1979; Finnegan 1983). However, there have been few reports on the long-term effects of methadone maintenance during pregnancy on the child's somatic and neurobehavioral(More)
Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive, unpleasant and inconvenient nature of current diagnostic procedures limits their applicability. No serum-based test is currently of sufficient sensitivity or specificity for widespread use. In the(More)
The relationship among maternal and observer ratings of infant temperament, observer ratings of maternal responsiveness, and maternal drug abuse habits, was studied in a population facing multiple risk factors. Intensity of maternal drug abuse was found to be negatively related to maternal ratings of infant temperament, and ratings of temperament were(More)
Prenatal opiate exposure has been shown to alter the pattern of sex-dimorphic behavior in male and female rats. To conduct an exploratory study of opiate effects in humans, we compared the sex-dimorphic behavior of male and female offspring of women maintained on methadone during pregnancy to that of demographically matched control subjects. Standardized(More)
INFORMATION is available in time literature on the nutrient 1-equirements of normal ad!ults living at high altitudes. As a result, the National Research Council's Committee on Dietary Allowances (1) has not mad!e any recommendlations as to time calorie, water, and protein allowances for individuals living at higim terrestrial environments. If anything, the(More)
Since 1977, we have been following the neurobehavioral development of two groups of children: a group born to women on methadone maintenance and a drug-free comparison group. This study used the data on the children evaluated at 36 months of age to determine whether distinct patterns of developmental outcome can be identified, and which medical, familial,(More)
Two groups of men consumed two levels of protein (1.4 and 2.8 g/kg body weight) during a 40-day experimental period. Physical activity and the sweat rates were fairly high during the entire experimental phase. Urinary nitrogen excretions remained fairly constant for both groups during the training and heavy physical activity periods. Nitrogen balances were(More)
Recently, hydrographic measurements have been used to argue that the meridional overturning circulation at 25 • N has decreased by 30% over the last 50 years. Here we show that the most likely interpretation consistent with this approach (i.e., with the dynamic method together with a level-of-no-motion assumption and Ekman dynamics) is that any decrease in(More)
Knowledge about the effects of prenatal drug exposure on early development is reviewed within an ecological framework. The intersecting influences on maternal and child behavior in the early caregiving environment are considered, and similarities reported for drug-exposed children and other high-risk groups are noted. Data from a sample of 90 dyads are used(More)