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- Thomas Auckenthaler, Volker Blum, +6 authors Paul R. Willems
- Parallel Computing
- 2011

The computation of selected eigenvalues and eigenvectors of a symmetric (Hermitian) matrix is an important subtask in many contexts, for example in electronic structure calculations. If a significant portion of the eigensystem is required then typically direct eigensolvers are used. The central three steps are: reduce the matrix to tridiagonal form, compute… (More)

- P Schickor, W Metzger, W Werel, H Lederer, H Heumann
- The EMBO journal
- 1990

Three characteristic footprinting patterns resulted from probing the Escherichia coli RNA polymerase T7 A1 promoter complex by hydroxyl radicals in the temperature range between 4 degrees C and 37 degrees C. These were attributed to the closed complex, the intermediate complex and the open complex. In the closed complex, the RNA polymerase protects the DNA… (More)

Obtaining the eigenvalues and eigenvectors of large matrices is a key problem in electronic structure theory and many other areas of computational science. The computational effort formally scales as O(N(3)) with the size of the investigated problem, N (e.g. the electron count in electronic structure theory), and thus often defines the system size limit… (More)

- H LEDERER, A J SINCLAIR
- The Journal of pathology and bacteriology
- 1954

OBJECTIVE
To evaluate analgesic and sedative effects of medetomidine hydrochloride in dogs and to compare effects with those of xylazine hydrochloride.
DESIGN
Randomized, controlled trial.
ANIMALS
184 dogs that required sedation or analgesia for completion of minor diagnostic or therapeutic procedures.
PROCEDURE
Dogs were sedated with medetomidine,… (More)

- H Lederer, R P May, J K Kjems, W Schaefer, H L Crespi, H Heumann
- European journal of biochemistry
- 1986

Neutron small-angle scattering studies of single protein subunits in a protein-DNA complex require the adjustment of the neutron scattering-length densities of protein and DNA, which is attainable by specific deuteration of the protein. The neutron scattering densities of unlabelled DNA and DNA-dependent RNA polymerase of Escherichia coli match when RNA… (More)

The solution structure of a DNA fragment of 130 base pairs and known sequence has been investigated by neutron small-angle scattering. In 0.1 M NaCl, the overall structure of the DNA fragment which contains the strong promoter A1 of the Escherichia coli phage T7 agrees with that expected for B-DNA. The neutron scattering curve is well fitted by that of a… (More)

In this paper we demonstrate that neutron small angle scattering is a suitable method to study the spatial arrangement of large specific protein-DNA complexes. We studied the complex of DNA-dependent RNA polymerase of Escherichia coli and a 130 base-pair DNA fragment containing the strong promoter A1 of bacteriophage T7. Contrast variation of the complex… (More)

The spatial arrangement of Tet repressor dimer, both free and in complex with an 80 bp DNA fragment spanning the wild-type Tn10-encoded tet transcriptional control sequence containing a tandem repeat of two operators, has been determined by neutron small-angle scattering. The active, free Tet repressor dimer is an elongated and flat molecule with a maximum… (More)

- S. Borowski, S. Thiel, R. Tisma, H. Lederer
- 2002

We present a massively parallel implementation to perform quantum dynamical wave packet calculations of molecules on surfaces. The employed algorithm propagates the wavefunction via the time-dependent Schrödinger equation within a finite basis representation by Split and Chebyshev schemes, respectively. For the parallelization, a problem adapted data… (More)