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Journals and Conferences
The larvicidal properties of 16 extracts of four Moroccan medicinal plants: Calotropis procera (Wild.), Cotula cinerea (L.), Solanum sodomaeum (L.) and Solanum elaeagnifolium (CAV.) were tested against Anopheles labranchiae mosquito larvae. Among the extracts tested, nine exhibited high larvicidal activity with LC(50) (24 h) ranging from 28 to 325 ppm.
The present study indicates the efficacy of extracts and fractions of Quercus lusitania var. infectoria galls (Oliv.) as larvicidal agents and their possible use in biological control of Culex pipiens, the urban nuisance mosquito. Extracts and fractions were tested against second and fourth instar larvae. The LC(50) values of gallotannins were 335 and 373… (More)
The extracts of six plants selected on the basis of folk-medicine reports were examined for their antibacterial effects against eight pathogenic bacteria. The results showed that n-butanol extract of Calotropis procera proved to be the most effective against the bacteria tested using the paper disc diffusion method. The antiprotozoal activity was also… (More)
Investigations were carried out to evaluate the hypoglycaemic activity of the infusions of Globularia alypum and Zygophyllum gaetulum. Oral and intraperitoneal administration of the plants (0.7 g/kg) produced a significant hypoglycaemic effect in normal as well as in hyperglycaemic rats. The infusions increased significantly plasma insulin levels in normal… (More)
Potassium fluoride doped natural phosphate, inexpensive and environmentally friendly catalyst, is shown to be an efficient basic catalyst for the N1/N9 alkylation of different nucleobases as synthons for PNAs.
The aqueous infusion of the aerial parts of Zygophyllum gaetulum Emb. and Maire was tested orally (1 g/kg body weight) for hypoglycemic activity in alloxan-induced diabetic rats. The infusion was partitioned between water and butanol to yield a butanol soluble fraction (B), and an aqueous fraction (W) which on reduction in volume gave a precipitate (WP) and… (More)
A series of new homo and heterodimers of ddI has been synthesized. A glutarate diester spacer was used to covalently couple ddI onto ddI, AZT or d4T.
Cycloaddition of 7a, b with 6 gave, after separation and deprotection, two regioisomers 10a, b and 11a, b. The deprotected acyclic nucleoside 10a used as the precursor for the preparation of 4-amino (12), 4-methylamino (13), 4-benzylamino (14), 4-methoxy (15) and 4-hydroxy (16) analogues. All acyclic nucleosides were evaluated for their inhibitory effects… (More)
Zygophyllum gaetulum leaves are one of several traditional remedies used for diabetes treatment in Morocco. Its ability to lower the blood glucose was studied in 13 patients with non-insulin-dependent diabetes mellitus. The reaction time of the Z. gaetulum aqueous extract at a single oral dose (440 mg/kg) producing a significant hypoglycaemic effect is 6 h… (More)
The synthesis of 1,2,3-triazole acyclonucleosides 7a-h via 1,3-dipolar cycloaddition of N-9/N-1-propargylpurine/pyrimidine 2a-h with azido-pseudo-sugar 4 is described and none of them had anti-HIV activity.