H. L. Zhang

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MicroRNAs play critical roles in the development and progression of colorectal cancer (CRC). miR-154 acts as a tumor suppressor in several tumors; however, its role in CRC is poorly understood. Herein, we found that miR-154 was decreased in CRC tissues and cell lines. Ectopic expression of miR-154 remarkably suppressed cell proliferation and colony(More)
Selenoprotein U (SelU) may regulate a myriad of biological processes through its redox function. In chicks, neither the nucleotide sequence nor the amino acid sequence is known. The main objectives of this study were to clone and characterize the chicken Selu gene and investigate Selu messenger RNA (mRNA) and protein expression in chicken tissues. The(More)
Detecting biotic resistance to biological invasions across large geographic areas may require acknowledging multiple metrics of niche usage and potential spatial heterogeneity in associations between invasive and native species diversity and dominance. Determine (1) if native communities are resistant to biological invasions at macroscales; (2) the metrics(More)
Current evidence indicates that the abnormal expression of chemokines or their receptors, such as CXC chemokine receptor-4 (CXCR4), is positively correlated with the development, progression and metastasis of tumor cells. However, the role of CXCR4 in neuroblastoma and its response to chemotherapy remain largely unclear. In addition, forkhead box 3 (Foxp3),(More)
BACKGROUND Accumulating databases in human genome research have enabled integrated genome-wide study on complicated diseases such as cancers. A practical approach is to mine a global transcriptome profile of disease from public database. New concepts of these diseases might emerge by landscaping this profile. METHODS In this study, we clustered human(More)
Not accounting for spatial heterogeneity in ecological analyses can cause modeled relationships to vary across spatial scales, specifically different levels of spatial resolution. These varying results hinder both the utility of data collected at one spatial scale for analyses at others and the determination of underlying processes. To briefly review(More)
A bacterial strain P2 capable of degrading 3,5,6-trichloro-2-pyridinol (TCP) was isolated and characterized. Phylogenetic analysis based on 16S rRNA gene sequence indicated that it belonged to the genus of Cupriavidus, because it showed the highest sequence similarity to Cupriavidus pauculus LMG 3413T (99.7 %) and DNA–DNA relatedness value between strain P2(More)
Feed-in-Tariff (FiT) mechanisms have been important in boosting renewable energy, by providing a long-term guaranteed subsidy of the kWh-price, thus mitigating investment risks and enhancing the contribution of sustainable electricity. By ongoing PV development, the contribution of solar power increases exponentially. Within this significant potential, it(More)
The changing mode of urban development through time can bring a varied landscape mosaic accompanied by spatial-temporal differentiation of urban vegetation. Hong Kong as an ultra-compact city generates intense interactions between trees and urban fabric to highlight urbanization effects on tree communities. The study areas cover public housing estates which(More)