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In a double-blind placebo-controlled randomized study the influence of a cholinergic nootropic (WEB 1881 FU) on event-related brain potentials (ERPs) related to memory performance was investigated. Two different encoding modes were imposed on the subjects, who had to memorize word lists. No significant drug effects were obtained on memory performance and(More)
The spontaneous EEG, pattern reversal VEPs, and the P300 wave were studied in patients with liver cirrhosis and early stages of hepatic encephalopathy (HE). The sensitivities of the different neurophysiological methods in the early stages of hepatic encephalopathy were compared with each other and with several neuropsychological tests. P300 latency was(More)
We performed positron emission tomography (PET) using 18F-labeled 2-F-2-deoxyglucose in 13 patients with systemic lupus erythematosus (SLE). Ten of them had clinical signs of central nervous system involvement (NP-SLE). All patients with neurologic symptoms showed pathologic changes on PET, always in accordance with the clinical state. Three patients(More)
The cerebrospinal fluid was examined in 48 patients with 49 status epileptici. A cerebral process was the cause of 27 status epileptici. The available data were subjected to a multifactorial analysis in order to find out whether individual factors or combinations of factors would permit to make relevant statements about a cerebral process being the possible(More)
Although endogenous event-related potentials (ERPs) have been successfully used in psychology, they have largely been neglected in the study of psychotropic substances. In the present paper an overview is given of the diversified concepts of ERP research and useful adaptations of these approaches to psychopharmacological questions are shown. In particular,(More)
The time course of the effects of caffeine (200 mg), diazepam (8 mg) and placebo on CNV magnitude, reaction time and state of mood was investigated in normal volunteers using a double-foreperiod paradigm. CNV changes were quantified by means of a linear robust fitting technique. In general, a reduction of amplitude was found for diazepam and an enhancement(More)
A multicenter, prospective, placebo-controlled, double-blind trial was conducted to investigate the efficacy of intravenous infusion therapy with pentoxifylline over fourteen days in patients suffering from angiographically confirmed chronic peripheral occlusive arterial disease, Fontaine stage II, with at least a six-month history. After a washout phase of(More)
The study was designed to examine the clinical applicability and use of computer-assisted EEG-analysis in comparison to visual EEG-analysis in patients with minor head injuries. For this in 31 patients the following examinations were performed within the first 24 hours, one, three and eight weeks after traumatization: EEG, neurological examination and(More)