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Neurons that synthesize GnRH control the reproductive axis and migrate over long distances and through different environments during development. Prior studies provided strong clues for the types of molecules encountered and movements expected along the migratory route. However, our studies provide the first real-time views of the behavior of GnRH neurons(More)
The preoptic area/anterior hypothalamus (POA/AH) is sexually dimorphic in many vertebrates. We have defined specific cell populations within the POA/AH using immunocytochemical markers for estrogen receptor beta (ERbeta) and the R1 subunit of the GABA(B) receptor (GABA(B)R1). Our previous finding of sex differences in cell migration in this region in(More)
Many studies suggest that migratory guidance cues within the developing brain are diverse across many regions. To better understand the early development and differentiation of select brain regions, an in vitro method was developed using selected inbred and transgenic strains of embryonic mice. In particular, organotypic slices are used to test factors that(More)
Estrogen receptor (ER) expression and regulation is vital to the correct functioning of the neuroendocrine brain. Islet-1 (Isl-1) is a LIM homeodomain-containing transcription factor that has been implicated in neuronal differentiation, is located in the hypothalamus, and can alter ER function in vitro. We have determined that Isl-1 is localized in several(More)
Museum fish collections possess a wealth of anatomical and morphological data that are essential for documenting and understanding biodiversity. Obtaining access to specimens for research, however, is not always practical and frequently conflicts with the need to maintain the physical integrity of specimens and the collection as a whole. Non-invasive(More)
(Affiliations are available in the online edition) ABSTRACT We present five band imaging of the Vega debris disc obtained using the Herschel Space Observatory. These data span a wavelength range of 70−500 μm with full-width half-maximum angular resolutions of 5.6−36.9. The disc is well resolved in all bands, with the ring structure visible at 70 and 160 μm.(More)
The delivery and interactive rendering and segmentation of magnetic resonance imaging (MRI) data over the web for the Digital Fish Library (DFL) project poses specific challenges in both complexity of the application and with the size of the data sets. We describe how to develop such an application, the required infrastructure, and the integration with a(More)
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