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Neurophysiological changes caused by parallel treatment with inorganic lead and dimethoate (a combination of possible health risk at population level) were investigated in different phases of the ontogenesis. Wistar rats were treated by gavage with lead (80.0 or 320.0 mg/kg); with dimethoate (7.0 or 28.0 mg/kg), or with their combination on days 5-15 of(More)
The treatment of primary central nervous system lymphoma (PCNSL) with chemo- and radiotherapy is efficient in terms of tumor response. However, time to tumor progression often is of short duration and leptomeningeal relapse is common. We present a 66-year-old man in third relapse of a CD20-positive PCNSL. After treatment with intravenous and(More)
Behavioural and electrophysiological changes caused by inorganic cadmium were investigated in the offspring of female Wistar rats. Dams were given 3.5, 7.0 or 14.0 mg kg(-1) cadmium (cadmium chloride dissolved in distilled water) in three different treatment regimes: days 5-15 of pregnancy; days 5-15 of pregnancy + 4 weeks of lactation; days 5-15 of(More)
— When visualizing data, spatial and temporal references of these data often have to be considered in addition to the actual data attributes. Nowadays, structural information is becoming more and more important. Hierarchies, for instance, are frequently applied to help dealing with large and complex data. Hence, a visual depiction of hierarchical structures(More)
Mercury is a neurotoxic compound causing irreversible disorders of the central and peripheral nervous system. In some of the previous human and experimental studies mercury also affected some functional neurological parameters such as EEG, and cortical evoked potentials. In the present study, the effect of subchronic (4, 8, and 12 weeks) relatively(More)
1. Three consecutive generations of Wistar rats were orally treated by gavage with 3.5, 7.0 or 14.0 mg/kg cadmium (in form of cadmium chloride diluted in distilled water) over the period of pregnancy, lactation and 8 weeks after weaning. 2. Behavioural (open field behaviour) and electrophysiological (spontaneous and evoked cortical activity, etc.)(More)
In this paper we propose a new a{posteriori error estimator for a weakly singular integral equation concerned with a direct boundary element approach for a Dirichlet problem with a second order elliptic partial diier-ential operator. The method is based on an approximate solution of a second kind Fredholm integral equation by a Neumann series to estimate(More)
The behavioral effects of subchronic exposure of male Wistar rats to the organophosphorus compound parathion-methyl (for 6 weeks 1/50 or 1/100 of LD50, PO) were studied. Open-field (OF) and elevated plus-maze (EPM) tasks were used to decide whether or not the compound can affect behavior. Significant effects were measured in the OF activity during the first(More)
Wistar rats were continuously treated with 7.0, 10.5, 14.0, 28.0 mg/kg (1/100, 1/75, 1/50 and 1/25 LD50) of dimethoate per os including the pregnancy of dams and the lactation period of pups as well as in adulthood for three subsequent generations. The EEG of male rats of each generation was recorded at the age of 12-13 weeks. The mean frequency, mean(More)