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Meningeal involvement (MI) by non-Hodgkin's lymphoma (NHL) was seen in 38/602 patients (6.3%). In relation to histologic subtype the frequency of MI was: Follicular small cleaved and mixed cell 2/128 (1.6%), small lymphocytic and diffuse small cleaved cell 2/83 (2.4%), large cell and immunoblastic 13/295 (4.5%), small noncleaved cell 6/31 (19%),… (More)
Of 602 patients treated for non-Hodgkin's lymphomas, 9 developed overt acute nonlymphocytic leukemia or preleukemia with refractory cytopenia and cytogenetic abnormalities of the bone marrow. A Kaplan-Meier estimate of the cumulative probability of leukemic complications was 6.3 +/- 2.6% (mean +/- SE) 7 years after start of treatment. All 9 patients with… (More)
Long-term outcome for 127 patients with follicular low-grade lymphoma was investigated. Therapy included radiotherapy (n = 23), low toxicity chemotherapy with or without radiotherapy (n = 76), or more intensive chemotherapy (n = 22). 6 patients had no initial therapy. Complete remission was obtained in 67% of patients. For patients under 60 years of age… (More)
A family presented with a papular vesiculo-bullous eruption of the skin, found to be caused by the snake mite, Ophionyssus natricis (Cervais, 1844). A pet python was the primary host. Treatment of the animal and its environment led to clearance of the human skin lesions.
Ammonium sulphate fractionation of human serum showed that two fractions contained an inhibitor of cluster and colony formation in agar cultures of human bone marrow cells. Further investigations demonstrated this inhibition to be caused by lipoproteins. When freshly prepared, only light density lipoproteins (LDL) were found to be inhibitory. During… (More)
Human bone marrow cells from normal subjects were density-separated in continuous density gradients of the Percoll medium. The distribution of cells showed a linear relationship between morphologic maturation and increasing density. The method was used to characterize the target cell of the growth-stimulating effect of ultrasonically irradiated (UI) serum.… (More)
Measurements of nuclear size and differential counts among six lymphoma cell types were performed on H & E stained sections. In differential counting, the definition of cell types was based on nuclear shape, chromatin pattern, and nucleoli. In a pilot study comprising 93 patients we found actual nuclear size inadequate for use in lymphoma classification.… (More)