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OBJECTIVE The principal MRI features of hippocampal sclerosis are volume loss and increased T2 weighted signal intensity. Minor and localised abnormalities may be overlooked without careful quantitation. Hippocampal T2 relaxation time (HT2) can be quantified, but previously has only been measured on a few thick coronal slices with interslice gaps. In this(More)
On neuropathological investigation of eight cases with primary generalized epilepsy, none showed elective parenchymal necrosis, which is regarded (qualitatively and topologically) as characteristic of epilepsy in classical neuropathology. In seven of the eight cases, however, marked microdysgenesis with varying regional distribution was found. These(More)
These guidelines apply to patients whose seizures have not been controlled by antiepileptic drugs and who are being evaluated for possible surgery. They are supplemental to the general ''Recommendations for Neuroimaging of Patients with Epilepsy. " 2. GOALS In individual patients undergoing presurgical evalua-a. Delineation of structural and functional(More)
Malformations of cortical development (MCD) are a common etiology for epilepsy. Laminar heterotopia, bilateral subependymal heterotopia, and lissencephaly have a genetic basis. No gene mutations have yet been identified in patients with focal cortical dysplasias. The aim of this study was to use quantitative morphometric tools to determine if there were(More)
1. PREAMBLE These guidelines are intended to apply to patients with a clear diagnosis of epilepsy. They have been specifically formulated for the management of newly diagnosed patients and those with chronic epilepsy who have not been fully evaluated. They are not designed for full investigation of patients for possible surgical treatment. 2. AIMS AND(More)
PURPOSE David Taylor and Murray Falconer suggested that some patients may develop a psychotic illness after resection of a ganglioglioma that led to intractable seizures. They implied that the mechanism of this association remained unclear. This concept is currently not universally accepted (M. Trimble, personal communication). METHODS We studied six(More)