H J L van der Want

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BACKGROUND Obesity promotes inflammation in adipose tissue (AT) and this is implicated in pathophysiological complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Although based on the classical hypothesis, necrotic AT adipocytes (ATA) in obese state activate AT macrophages (ATM) that then lead to a sustained chronic(More)
Neuronal protein aggregates are considered as pathological hallmarks of various human neurodegenerative diseases, including the so-called CAG-repeat disorders, such as spinocerebellar ataxia Type 6 (SCA6). Since the immunocytochemical findings of an initial post-mortem study using a specific antibody against the disease protein of SCA6 (i.e., pathologically(More)
Human corneas were studied by means of electron microscopy after culture at 31 degrees C for two to 20 days in a medium containing 8% dextran T 500. Dextran T 500, a strong osmotic agent, was included in the culture medium to prevent excessive swelling of the cornea. In order to exclude the possibility that the observed effects were the result of osmotic(More)
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