H J Hoppen

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The sleeve anastomotic technique was used to enhance the longer term patency and healing of polyurethane-based (PU) microvenous prostheses (ID: 1 mm, length: 5 mm, wall thickness: 0.2 mm; n = 34) in the rat femoral vein. In the control group, PU prostheses (n = 12) were implanted by means of the conventional end-to-end technique, and all were found to be(More)
The sequential thrombotic events which occur after implantation of microvenous prostheses prepared from a polyurethane-based material (I.D. 1 mm, length 5 mm, n = 36) into the rat femoral vein by means of the conventional end-to-end suture technique were evaluated by direct inspection and by scanning electron microscopy during the first 24 postoperative(More)
Biodegradable polyurethane-based (PU) nerve guides, instilled with or without ACTH4-9 analog (a melanocortin) were used for bridging an 8 mm gap in the rat sciatic nerve and were evaluated for function and histological appearance after 16 weeks of implantation. Autologous nerve grafts functioned as controls. The guides successfully enabled the sciatic nerve(More)
A synthetic biodegradable nerve guide was constructed of two polymeric layers: an inner microporous layer prepared from a copolymer of L-lactide and epsilon-caprolactone (pore size range 0.5-1 micron) and an outer microporous layer prepared from a polyurethane/poly(L-lactide) mixture (pore size range 30-70 microns). This nerve guide was used to bridge a 7(More)
A semipermeable membrane for the encapsulation of the islets of Langerhans, consisting of a microporous polymer network, has been developed. The polyurethane network was formed by cross-linking a mixture of linoleic acid and a linear poly(etherurethane) with dicumyl peroxide. Cross-linking the polyurethane impedes the formation of hard domains.(More)
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