H. H. Wagener

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Based upon the results of a bioequivalence study in 18 male and female healthy volunteers receiving each ibuprofen 400 mg at a time interval of 3 days the issue of the intrasubject variation is discussed. It was shown that there was bioequivalence as to the parameters Cmax, AUC0-tlast und AUC0-infinity in the volunteers who repeatedly received the same(More)
In a within-subject comparative trial in 16 healthy volunteers, the bioequivalence of two sulpiride 200 mg preparations was tested using a model-free method of calculation as well as assuming 2- and 3-compartment models. As to AUC act., AUC inf. and Cmax, the test preparation was shown to be significantly superior. Some other differences were found(More)
Pharmacological and limited toxicological screening tests have been performed in order to provide an initial assessment of a new hypotensive substance, 2-[1-(2,6-dichlorphenoxy)-ethyl-2-imidazoline hydrochloride (lofexidine, Lofetensin and Loxacor). After intravenous and intraduodenal administration, this new delta 2-imidazoline compound caused a(More)
As in the case of systemically administered drugs, there is also a requirement for reliable kinetic evidence for the clinical effectiveness of local therapeutic NSAIDs. The conditions required for this are discussed, and compared with provisions already existing in EC countries. On the basis of a comprehensive review of the literature, it is shown that(More)
In an extensive pharmacological screening of "essential" phospholipids (EPL) antilipemic, hepatoprotective, broncholytic, as well as slight choleretic effects were found and the substance decreased capillary permeability. There was practically no influence on other functions or systems including the vegetative system (heart, circulation, respiration).