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Azaperone, acepromazine, xylazine and diazepam were tested for mutagenic activity. To screen these veterinary drugs we used the Salmonella/microsome test on 5 histidine-auxotrophic strains, with and without metabolic activation. Azaperone and xylazine were found to be weakly mutagenic.
In previous experiments, azaperone was found to be weakly mutagenic, after metabolic activation, in the Ames assay. In this study, we subjected metabolites found in rat and swine to the Salmonella/microsome test. 5 histidine-auxotrophic strains were used. The main metabolites could be classified as weakly mutagenic substances.