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Nascent polypeptide-associated complex (NAC) was initially found to bind to any segment of the nascent chain except signal sequences. In this way, NAC is believed to prevent mistargeting due to binding of signal recognition particle (SRP) to signalless ribosome nascent chain complexes (RNCs). Here we revisit the interplay between NAC and SRP. NAC does not(More)
In this paper, a design methodology for the design of microelectronic systems which includes hardware and software for open-loop and closed-loop control will be presented. An integrated approach to specification and design, analysis and simulation of the overall system has been developed. This provides for a systematic, computer aided approach to(More)
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