H Fehling

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.

Volker Siffrin, Helena Radbruch, +13 authors Frauke Zipp
Immunity
2010

Neuronal damage in autoimmune neuroinflammation is the correlate for long-term disability in multiple sclerosis (MS) patients. Here, we investigated the role of immune cells in neuronal damage… (More)

Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.

Stefan Irion, Raedun L. Clarke, +4 authors Gordon M. Keller
Development
2010

The efficient and reproducible generation of differentiated progenitors from pluripotent stem cells requires the recapitulation of appropriate developmental stages and pathways. Here, we have used… (More)

Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.

Andreas Müller, Patrick O Kaiser, +8 authors Wolf-Dietrich Hardt
Cell host & microbe
2012

Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs).… (More)

Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo.

C Victorri Vigneau, Katalin Polgár, +7 authors Patricia S. Wilson
Journal of the American Society of Nephrology…
2007

The metanephric kidney is a mesodermal organ that develops as a result of reciprocal interactions between the ureteric bud and the blastema. The generation of embryonic stem (ES) cell-derived… (More)

The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation.

Gina Balciunaite, Rhodri Ceredig, H Fehling, Juan-Carlos Zúñiga-Pflücker, Antonius G. Rolink
European journal of immunology
2005

We have analyzed the roles of Notch and IL-7 signaling in the proliferation and differentiation of mouse progenitor thymocyte subpopulations cultured on Notch delta-like-1 ligand-expressing OP9… (More)

Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo.

Harmjan Kuipers, Frauke Marie Schnorfeil, H Fehling, Helmut Bartels, Thomas Brocker
Journal of immunology
2010

Dendritic cells (DCs) are central for the induction of T cell immunity and tolerance. Fundamental for DCs to control the immune system is their differentiation from precursors into various DC subsets… (More)

Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.

Fotini Gounari, Iannis Aifantis, +5 authors Boris Reizis
Nature immunology
2002

A transgenic reporter mouse strain, which expressed the human CD25 (hCD25) surface marker as a reporter under the control of the pre-T cell receptor alpha(pTalpha) promoter, was used to identify… (More)

Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.

Anne-Christine Flach, Tanja Litke, +9 authors Alexander Flügel
Proceedings of the National Academy of Sciences…
2016

Multiple sclerosis (MS) is caused by T cells that are reactive for brain antigens. In experimental autoimmune encephalomyelitis, the animal model for MS, myelin-reactive T cells initiate the… (More)

The Biological Activity of Natural and Mutant Ptα Alleles

Deena L Gibbons, Nataki C. Douglas, +6 authors Adrian C. Hayday
The Journal of Experimental Medicine
2001

selection is a major checkpoint in early thymocyte differentiation, mediated by successful expression of the pre-T cell receptor (TCR) comprising the TCR chain, CD3 proteins, and a surrogate TCR… (More)

Langerhans Cells In Vivo Maturation, Function, and Maintenance of Dicer-Dependent MicroRNAs Control

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