H. Farghali

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This present investigation was initiated to noninvasively evaluate the usefulness of intravenous gadopentetate dimeglumine (Gd-PTDM)-enhanced magnetic resonance imaging (MRI) in assessing the integrity of the blood-testis barrier (BTB). The intensity of different image slices was measured in pre- and post-Gd-PTDM images in rats receiving cytochalasin D or(More)
Estrogen-induced cholestasis is characterized by impaired hepatic uptake and biliary bile acids secretion because of changes in hepatocyte transporter expression. The induction of heme oxygenase-1 (HMOX1), the inducible isozyme in heme catabolism, is mediated via the Bach1/Nrf2 pathway, and protects livers from toxic, oxidative and inflammatory insults.(More)
Oxidative stress and apoptosis are proposed mechanisms of cellular injury in studies of xenobiotic hepatotoxicity. This study is focused on addressing the mutual relationship and early signals of these mechanisms in the D-galactosamine and lipopolysaccharide (D-GalN/LPS) hepatotoxicity model, with the help of standard liver function and biochemistry tests,(More)
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