H E Delemarre-van de Waal

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OBJECTIVES To study final height in girls with Turner's syndrome treated with once or twice daily injections of growth hormone (GH) in combination with low dose ethinyl oestradiol. DESIGN Until final height was reached, the effect of fractionated subcutaneous injections given twice daily was compared with once daily injections of a total GH dose of 6(More)
BACKGROUND To investigate in a group of short children born small for gestational age (SGA), the effects of 3 years of GH treatment vs. no treatment on bone age (BA), height and bone mineral density (BMD). Also, to evaluate the influence of the severity of growth retardation at start and the GH dose on the gain in height. PATIENTS AND METHODS The study(More)
UNLABELLED GH is known to improve height velocity in girls with Turner syndrome (TS) but the optimal dosage regimen has yet to be defined. OBJECTIVE We attempted to improve the growth response by trying to mimic normal pulsatile GH secretion more closely. DESIGN In a 2-year study the effect of fractionated twice daily (BID) was compared with once daily(More)
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