H. D. Preisler

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DMSO and other cryoprotective agents produce a pronounced increase on the phase transition temperature of phospholipid membranes, indicating an increased stability. The effects of DMSO and other cryoprotective agents, divalent cations, and local anaesthetics on the transition temperature of phospholipid membranes seem to correlate with their effects on the(More)
Cell cycle characteristics including labeling indices (LI), duration of S-phase (Ts), and total cell cycle time (Tc) were determined in 54 standard-risk, newly diagnosed patients with acute myeloid leukemia following an infusion of bromodeoxyuridine. Remission induction therapy consisting of cytosine arabinoside and daunomycin was then administered to all(More)
The vast majority of murine leukaemias are lymphoid in nature. They have been extensively used in chemotherapy studies, and the data obtained have to some extent been applicable to the treatment of mye-loid leukaemia in man, but their lymphoid nature has prevented them from being used to study the relationship between myeloid leukaemic cells and normal(More)
THE ADDITION of dimethylsulfoxide (DMSO) to suspension cultures of Friend leukaemia cells results in the erythroid differentiation of a substantial proportion of cells in the culture (Friend et al., 1971). The continuous presence of DMSO in the culture medium is not necessary for differentiation to occur since exposure of the cells to DMSO for 2 days(More)
The effects of C. parvum on RFM/UN myeloid leukaemia were studied. Mice inoculated with 7.0 mg but not 0.7 mg C. parvum i.p. survived significantly longer than untreated leukaemic mice (P less than 0.001). Administration of silica abrogated the effects of C. parvum, whilst polyvinyl pyridine-N-oxide prevented the inhibitory effects of silica. These studies(More)
Studies were conducted of the in vivo therapeutic potential of compounds which induce the differentiation of Friend leukaemia cells (FLC) in vitro. DBA2/J mice were inoculated with Friend leukaemia cells grown in tissue culture and at various times thereafter were treated with either N-methylacetamide, dimethylacetamide, or tetramethylurea. While survival(More)
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