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  • H C Hughes
  • 1977
The organization of thalamic afferents to the rat's visual cortex was investigated autoradiographically and through the retrograde transport of horseradish peroxidase (HRP) following infections into striate and peristriate cortex. The results revealed that Nucleus lateralis posterior (NLP) projects to a large peristriate cortical field that includes areas(More)
beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a specific binding partner of beta-glucocerebrosidase. This interaction involves a coiled-coil domain within the(More)
Saccadic reaction times (SRTs) were analyzed in the context of stochastic models of information processing (e.g., Townsend and Ashby 1983) to reveal the processing architecture(s) underlying integrative interactions between visual and auditory inputs and the mechanisms of express saccades. The results support the following conclusions. Bimodal(More)
Strategies to increase the extent of axonal regeneration in the adult CNS must address an array of intrinsic and environmental factors which influence neuritic outgrowth. In order to develop an in vivo model of axonal regeneration in which potential therapies may be assessed, we have quantified growth cones within demyelinated regions in the dorsal(More)
The present report describes the results of experiments designed to study supraspinal systems in the American opossum by several techniques. The data indicate that although spinal fibers from the opossum motor-sensory cortex are small and limited in their distribution, those from the brain stem are comparable in their origin, course, caudal extent and(More)
A comparison of biting attack induced by electrical stimulation of the cat hypothalamus with natural feline predatory attack revealed a high degree of similarity between the two behaviors. All major components of natural attack could be elicited by hypothalamic stimulation in cats not showing spontaneous attack, including stalking approach to prey, holding(More)
Pretreatment of the ischemic myocardium with verapamil protects against mitochondrial respiratory depression observed during ischemic arrest as well as during reperfusion. Since ischemic mitochondrial function appears not to be altered further by reperfusion, the purpose of this study is to identify a biochemical event affecting mitochondria that is(More)
The increased use of rats for laboratory studies has increased the urgency for a better understanding of their perception of painful or noxious stimuli and the means of obtunding such stimuli. Four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam, were evaluated in this study. Unlike(More)
The present study describes a wheel turn/tail flick paradigm that was designed to simultaneously assess nociceptive thresholds of responses organized at spinal and supraspinal levels of the CNS in the rat. The paradigm involves training rats to perform an operant wheel turn response in order to escape current applied to the tail. Thresholds for the(More)