H. C. Adams

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Dbs is a Rho-specific guanine nucleotide exchange factor (RhoGEF) that regulates neurotrophin-3-induced cell migration in Schwann cells. Here we report that Dbs regulates cell motility in tumor-derived, human breast epithelial cells through activation of Cdc42 and Rac1. Cdc42 and Rac1 are activated in T47D cells that stably express onco- or proto-Dbs, and(More)
The analysis of normal mammary morphogenesis is facilitated by the use of mammary fat pad transplantation. The recent experiments on analysis of normal mammary epithelial stem cell activity rely heavily on this technique. In this review, we discuss the known and unknown attributes of using Matrigel in the injection of the mammary epithelial cell suspension.(More)
T-cell lymphoma invasion and metastasis-inducing protein (Tiam1) is an Ras-related C3 botulinum toxin substrate (Rac)-specific guanine nucleotide exchange factor that was isolated based on its ability to induce a metastatic phenotype. In polarized migrating keratinocytes, Tiam1 is found at the leading edge, where it cooperates with the protease-activated(More)
The classical process of partitioning an array into subarrays is extended to a more useful array language operation. Various modes of partitioning are defined for different types of arrays, so that subarrays may vary over the original array in a nearly arbitrary manner. These definitions are motivated with several realistic examples to illustrate the value(More)
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