H. Brunnauer

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Most antihistamines are assumed to possess a more or less pronounced sedative potential in addition to their antihistaminic properties. Therefore, a singleblind three-way crossover study was designed to assess the influence of single-dose dimethindene maleate (new “once a day formulation”) on vigilance and performance vs. loratadine as reference and vs.(More)
Oxerutins (O-(beta-hydroxyethyl)-rutosides, HR, Venoruton) are available in different releasing galenical formulations for the treatment of chronic venous insufficiency (CVI). In order to investigate the biopharmaceutical relevance of the releasing properties of the galenical forms the therapeutic efficacy between the commercially available forms was(More)
The study investigated the local anaesthetic efficacy and its time course of dimethindene. The pilot-study was carried out with 8 healthy volunteers in a placebo-controlled, randomized, crossover design with four gel formulations [Dimethindene, non-occlusive (DNO) and occlusive (DO); Lidocaine (L); Placebo (P)]. Selective thermo-nociceptive stimulation(More)
Dimethindene maleate (Fenistil®), an, H1-receptor blocker, exists in the form of two enantiomers: S-(−)-dimethindene maleate and R-(+)-dimethindene maleate. These two enantiomers were tested for their antihistaminic and anti-anaphylactic properties in guinea-pigs. The S-enantiomer was much more active than the R-enantiomer. The ED50 for protection against a(More)
Dimetindene maleate (DMM, Fenistil, CAS 3614-69-5) a specific H1-receptor antagonist, is therapeutically used for the treatment of respiratory allergies, urticaria, itching dermatoses and generally pruritic sensations occurring with various diseases. As it exhibits local anaesthetic activity in the rabbit cornea and the local anaesthetic activity of a(More)
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