H. Andrew W. Neil

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BACKGROUND During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of microvascular complications than did those receiving conventional dietary therapy. We conducted post-trial monitoring to determine whether this improved glucose control persisted and(More)
OBJECTIVE To determine the relation between exposure to glycaemia over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes. DESIGN Prospective observational study. SETTING 23 hospital based clinics in England, Scotland, and Northern Ireland. PARTICIPANTS 4585 white, Asian Indian, and Afro-Caribbean UKPDS(More)
Introduction Type 2 diabetes is associated with a two to fourfold increased risk of both coronary heart disease and stroke. Case-fatality rates for myocardial infarction and stroke are also raised, emphasising the need for primary prevention. Findings of observational studies suggest that lipid lowering should have an important place in the primary(More)
OBJECTIVE To evaluate baseline risk factors for coronary artery disease in patients with type 2 diabetes mellitus. DESIGN A stepwise selection procedure, adjusting for age and sex, was used in 2693 subjects with complete data to determine which risk factors for coronary artery disease should be included in a Cox proportional hazards model. SUBJECTS 3055(More)
OBJECTIVE To determine the relation between systolic blood pressure over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes. DESIGN Prospective observational study. SETTING 23 hospital based clinics in England, Scotland, and Northern Ireland. PARTICIPANTS 4801 white, Asian Indian, and Afro-Caribbean(More)
BACKGROUND AND PURPOSE People with type 2 diabetes are at elevated risk of stroke compared with those without diabetes. Relative risks have been examined in earlier work, but there is no readily available method for predicting the absolute risk of stroke in a diabetic individual. We developed mathematical models to estimate the risk of a first stroke using(More)
BACKGROUND Familial hypercholesterolaemia (FH) affects approximately 1 in 500 people (10 million world-wide) and the elevated serum cholesterol concentrations lead to a more than 50% risk of fatal or non-fatal coronary heart disease by age 50 years in men and at least 30% in women aged 60 years. Based on a systematic literature search, we review the natural(More)
Plant sterols may be a useful additive therapy in the treatment of hypercholesterolaemic patients. The purpose of this study was to determine the effect of a fat spread enriched with vegetable oil sterols on plasma lipid, lipoprotein and apolipoprotein concentrations. A randomised double blind placebo-controlled crossover trial with two consecutive periods(More)
BACKGROUND High dietary intakes of fruit and vegetables are associated with reduced risks of cancer and cardiovascular disease. Short-term intensive dietary interventions in selected populations increase fruit and vegetable intake, raise plasma antioxidant concentrations, and lower blood pressure, but long-term effects of interventions in the general(More)
BACKGROUND We examined whether atorvastatin affects diabetic kidney disease and whether the effect of atorvastatin on cardiovascular disease (CVD) varies by kidney status in patients with diabetes. STUDY DESIGN The Collaborative Atorvastatin Diabetes Study (CARDS) randomized placebo-controlled trial. SETTING & PARTICIPANTS Patients with type 2 diabetes(More)