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OBJECTIVE Arterial distensibility (DC) and compliance (CC) are vessel wall properties of large arteries that can be measured non-invasively with a custom made vessel wall movement detector system (VWMDS). This study investigated the reproducibility of this device in 10 volunteers. METHODS To investigate intraobserver intrasession and intraobserver(More)
Afferent nerves from the kidney and mesentery reflexly influence the cardiovascular system when activated. To examine the specificity of these reflexes, comparisons were made of the regional hemodynamic responses elicited by intra-arterial infusion of various agents into the renal (ir) and mesenteric (im) circulation. Experiments were performed in conscious(More)
The effect of pentobarbitone anaesthesia and the effect of hypothermia associated with the anaesthesia on the blood clearance of indocyanine green (ICG) and of S(-)-acenocoumarol (AC) was investigated in male Wistar rats using the constant rate infusion technique. During anaesthesia, body temperature was regulated by heat supply. At normothermia (rectal(More)
Angiotensin II was applied daily in doses of 67 or 670 ng to a section of the chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs. During this one-week period, it caused a significant, dose-dependent increase in the vascular density index. The increase obtained with 670 ng daily was comparable to that after daily(More)
Effects of Captopril. Journal of Molecular and Cellular Cardiology (1991) 23, 1245-1253. This study was undertaken to investigate the alterations in interstitial DNA synthesis and collagen content in the non-infarcted left and right ventricle after induction of a myocardial infarction (MI) in the rat. MI was induced by ligation of the left anterior(More)
OBJECTIVE To compare the cardiovascular effects of 6 months of treatment with the angiotensin converting enzyme inhibitor perindopril and with the diuretic combination amiloride+hydrochlorothiazide, and to study possible persistence of observed treatment effects after discontinuation of antihypertensive therapy. DESIGN A placebo run-in period preceded a(More)
Vessel wall properties (distensibility coefficient and cross-sectional compliance) of the elastic common carotid artery (CCA) and the muscular femoral (FA) and brachial (BA) arteries were studied with a dedicated ultrasound system in 15 trained male cyclists and 15 healthy sedentary males matched for age, height, and weight. Simultaneously, arm blood(More)
BACKGROUND The timing and mechanisms of new blood vessel formation in the endometrium during the menstrual cycle are still largely unknown. In the present study we used the chick embryo chorioallantoic membrane (CAM) as an in-vivo assay for angiogenesis to assess the angiogenic potential of endometrium obtained at different stages of the menstrual cycle. (More)
This study describes the simultaneous measurement of hepatic arterial and portal venous blood flow in the pentobarbital anesthetized rat by means of electromagnetic flowmeters. Hepatic arterial flow was 0.21 +/- 0.02 mL/min/g liver, and portal venous flow was 1.53 +/- 0.19 mL/min/g liver (n = 20). Flows remained stable for more than 3 hr. A clear advantage(More)
Nicorandil (N) and isosorbide dinitrate (ISDN) are vasodilator drugs used in patients with angina. In 24 healthy male volunteers (18-32 years), the acute effect of a single oral dose (20 mg) of N and ISDN on arterial diameter (D), distensibility, and compliance of the elastic common carotid artery (CCA) and the muscular femoral (FA) and brachial (BA)(More)