Hélène Beaudry

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We report a novel transgenic mouse model in which the terminals of peripheral nociceptors can be silenced optogenetically with high spatiotemporal precision, leading to the alleviation of inflammatory and neuropathic pain. Inhibitory archaerhodopsin-3 (Arch) proton pumps were delivered to Nav1.8(+) primary afferents using the Nav1.8-Cre driver line. Arch(More)
We report a novel transgenic mouse model in which the terminals of peripheral nociceptors can be silenced optogenetically with high spatiotemporal precision, leading to the alleviation of inflammatory and neuropathic pain. Inhibitory archaerhodopsin-3 (Arch) proton pumps were delivered to Na v 1.8 ϩ primary afferents using the Na v 1.8-Cre driver line. Arch(More)
s The Journal of Pain S67 afferents, leading to the development of muscle pain. This work also suggests potential therapies for prevention of persistent muscle pain initiated by an ischemic insult. (367) Interrogating the role of peripheral opioid receptors using an optogenetic approach H Beaudry, I Daou, A Ribeiro-Da-Silva, and P S egu ela; McGill(More)
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