Hélène Barthelemy

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In situ, two types of dendritic cells (DCs) have been characterized in more detail: the interdigitating DCs of peripheral lymphoid tissues and the epidermal Langerhans cells. In order to characterize human thymic DCs, normal human thymus specimens were obtained from children undergoing cardiovascular surgery. In culture, DCs could be easily differentiated(More)
Progressive systemic sclerosis (PSS) is a mul t i sys tem d i sorder associa ted with immuno log i c abnormal i t i es . Recent studies have shown a reduc t ion in T-cell number , n o r m a l T-cells wi th receptors for the Fc p o r t i o n o f I g G (T#), decreased Tcells with receptors for the F c p o r t i o n o f I g M (T#), a b n o r m a l l y(More)
Bullous pemphigoid is a typical autoimmune disease. It is classically treated with systemic corticosteroids alone or combined with immunosuppressants. Cyclosporine A (CyA), a new immunosuppressive agent with high activity in organs and bone marrow transplantation, could be expected to prove effective in this disease owing to its action on lymphocytes. Seven(More)
The effects of cyclosporine were studied in nine patients suffering from pemphigus vulgaris. Of four patients treated with cyclosporine alone, only one cleared. Of four corticosteroid-resistant pemphigus vulgaris patients, all improved after cyclosporine addition to corticosteroids. The last patient treated from the beginning with a combined treatment(More)
Cyclosporin A (CyA) is a fungal peptide used as immunosuppressor in human organ transplantation. Increased hair growth appears to be a common side-effect of treatment, occurring in almost all patients treated with oral CyA. The development of hypertrichosis during CyA administration is not hormone-dependent; it may be mediated by a direct effect of the drug(More)
In rodent thymus, associations between dendritic cells (DC) and thymocytes have been suggested to be implicated in differentiation and/or maturation processes. In this study, we report intimate associations formed between human thymic DC and thymocytes in culture and we analyze their ultrastructural cell phenotype. Observations by phase contrast microscopy(More)
The skin and mucosal changes in vitamin deficiency are described. Pellagra, which is the oldest known cutaneous manifestation among vitamin deficiencies, is reviewed. Cutaneous alterations caused by deficiency of the water-soluble vitamins B6, C, B1 and biotin, B12, folic acid, and riboflavin result in more mucosal alterations and are discussed. Alterations(More)