Héctor M Perez

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BACKGROUND Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a population-level would help to understand how HLA-mediated selection drives the evolution of HIV-1. METHODOLOGY/PRINCIPAL FINDINGS We undertook a study of the(More)
Since the introduction of combined antiretroviral therapy (cART) regimens in the middle of the 1990s, HIV infection has turned into a chronic manageable disease instead of the death sentence it used to be. Nowadays, with the expansion of this kind of highly active therapy, the survival rate is almost equal to that of the general population [1,2]. It has(More)
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