Héctor Arango

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[1] Decadal fluctuations in salinity, nutrients, chlorophyll, a variety of zooplankton taxa, and fish stocks in the Northeast Pacific are often poorly correlated with the most widely-used index of large-scale climate variability in the region the Pacific Decadal Oscillation (PDO).We define a new pattern of climate change, the North Pacific Gyre Oscillation(More)
BACKGROUND It is believed that BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are scant data on the prevalence and spectrum of mutations, genotype/phenotype correlations, tumor histology, and family history characteristics. To address this gap, the authors conducted a(More)
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association study of 507,094 SNPs in 1,768 individuals with ovarian cancer (cases) and 2,354 controls, with follow up of 21,955 SNPs in 4,162 cases and 4,810 controls,(More)
OBJECTIVE To determine whether lysophosphatidic acid (LPA) and other lysophospholipids (LPL) are useful markers for diagnosis and/or prognosis of ovarian cancer in a controlled setting. METHOD Plasma samples were collected from ovarian cancer patients and healthy control women in Hillsborough and Pinellas counties, Florida, and processed at the University(More)
OBJECTIVE To identify sentinel lymph nodes using intraoperative lymphoscintigraphy. METHODS Technetium-99-labeled sulfur colloid was injected at the site of primary vulvar carcinoma. An intraoperative gamma counter was used to identify one or more sentinel lymph nodes. RESULTS Ten patients underwent bilateral inguinal and femoral lymphadenectomy. The(More)
OBJECTIVE To find whether aspirin (acetylsalicylic acid, ASA) inhibits the growth of endometrial cancer cells in vitro in a way similar to that in colorectal cancer cells and to investigate the mechanisms by which aspirin might lead to growth inhibition. METHODS Ishikawa human endometrial tumor cells were grown in the presence of ASA (1-5 mM) for 96(More)
OBJECTIVE To assess the accuracy of intraoperative lymph node palpation for identifying lymph node metastasis in gynecologic malignancies. METHODS We prospectively evaluated 126 women who had lymphadenectomies for staging of various gynecologic malignancies from August 1995 to June 1997. Surgeries were done by obstetrician-gynecologists with subspecialty(More)
BACKGROUND The English literature contains infrequent reports of neuroendocrine carcinoma during pregnancy. The chemotherapy for this type of malignancy can cause severe nausea and neutropenia. We used recently developed modalities to ameliorate these side effects. CASE A 22-year-old woman, gravida 4, para 2-0-1-2, presented at 24 weeks' gestation with a(More)
PURPOSE On a long-term basis patients with continent urinary diversions may have an acceptable number of complications, such as urinary incontinence. We report on a new surgical technique for treatment of the incompetent anti-incontinence segment. MATERIALS AND METHODS Seven patients presented with a large capacity, low pressure reservoir and an(More)