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Gallium(III) complexes of DOTA and DOTA-monoamide: kinetic and thermodynamic studies.
TLDR
The kinetic inertness of both chelates is extremely high and approves the application of Ga(3+) complexes of such DOTA-like ligands in molecular imaging. Expand
Synthesis and characterization of a hypoxia-sensitive MRI probe.
TLDR
The results suggest that the nitroimidazole derivative might serve as a molecular reporter for discriminating hypoxic versus normoxic tissues by MRI. Expand
Equilibrium and formation/dissociation kinetics of some Ln(III)PCTA complexes.
TLDR
Data indicate that the Ln(PCTA) complexes exhibit the fastest formation rates among all lanthanide macrocyclic ligand complexes studied to date, and are likely to be inversely proportional to the proton concentration. Expand
Modulation of water exchange in Eu(III) DOTA-tetraamide complexes: considerations for in vivo imaging of PARACEST agents.
TLDR
Water exchange in lanthanide(III)-DOTA type complexes is investigated and it is shown that introduction of steric bulk into the amide side-chain arms of the europium(III) complexes not only favors formation of the mono-capped twisted square antiprism coordination isomers, the isomer that is generally less favourable for CEST, but also accelerates water exchange. Expand
Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH.
TLDR
Examination of the nuclear magnetic relaxation dispersion and relaxivity temperature profiles, coupled with information from potentiometric titrations, shows that the amphoteric character of the phosphonate side chains enables rapid prototropic exchange between the single bound water of the complex with the bulk water thereby giving Gd1 a unique pH-dependent relaxivity that is quite useful for the pH mapping of tissues by MRI. Expand
Properties, solution state behavior, and crystal structures of chelates of DOTMA.
TLDR
It is reported that the tetramethylated DOTA derivative, DOTMA, possess several properties that, from an imaging agent development point of view, are more advantageous than those of the parent DOTA. Expand
Investigations into whole water, prototropic and amide proton exchange in lanthanide(III) DOTA-tetraamide chelates.
TLDR
This paper reports the results of studies using chemical exchange saturation transfer (CEST) and some more recently reported chelates to re-examine the exchange processes in this class of chelate and finds that the conclusions of Parker and Aime are solid. Expand
Albumin-binding PARACEST agents
TLDR
Fluorescence displacement studies using reporter molecules indicate that both Gd2 and Gd3 displace dansylsarcosine from site II of HSA with inhibition constants of 32 and 96 μM, respectively, but neither complex significantly displaces warfarin from site I. Expand
Novel CDTA-based, Bifunctional Chelators for Stable and Inert MnII Complexation: Synthesis and Physicochemical Characterization.
TLDR
Given the exquisite compromise between thermodynamic stability, kinetic inertness, and relaxivity achieved by [Mn(4-HET-CDTA], appropriately designed CuAAC-conjugates of 6a/6b are promising precursors for the preparation of targeted, bioresponsive, or high relaxivity manganese-based PET/MR tracers (52g/55 MnII) and MR contrast agents (MnII). Expand
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