Gyu Il Kim

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Anti-angiogenesis is regarded as an effective strategy for cancer treatment, and vascular endothelial growth factor (VEGF) plays a key role in the regulations of angiogenesis and vasculogenesis. In the present study, the authors synthesized five novel nicotinamide derivatives which structurally mimic the receptor tyrosine kinase inhibitor sunitinib and(More)
Glucoamylase from Endomycopsis species 20-9 was immobilized on AE-cellulose by covalent binding with the use of glutaraldehyde. The activity of immobilized preparations was measured as a function of pH, buffer concentration, temperature and immobilization time. The most active preparations of immobilized glucoamylase were obtained in 0.2 M Na-phosphate(More)
Previously, we have found that BRN-103, a nicotinamide derivative, inhibits vascular endothelial growth factor (VEGF)-mediated angiogenesis signaling in human endothelial cells. During our continuous efforts to identify more potent anti-angiogenic agents, we synthesized various nicotinamide derivatives and evaluated their anti-angiogenic effects. We found(More)
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