Gy. Szegedi

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We studied the effect of 1-year transdermal estrogen replacement therapy (ERT) on bone mineral density (BMD) and biochemical markers of bone turnover in osteopenic postmenopausal systemic lupus erythematosus (SLE) patients in a randomized, double-blind, placebo-controlled trial. SLE patients were randomly allocated to treatment (estradiol; 50 μg transdermal(More)
The aim of this cross-sectional study was to determine the prevalence of reduced bone mineral density (BMD) in a group of female SLE patients and to identify factors predictive of reduced BMD. Femoral neck (FN) and lumbar spine (LS) dual-energy X-ray absorptiometry results were evaluated in 79 pre- and postmenopausal women with SLE aged (mean, range) 49(More)
In a new, simple, and fast flow-cytometric method for the simultaneous measurement of phagocytic activity of human neutrophils and monocytes in whole blood, the fluorescence capability of the well-known vital stain, neutral red was used. The incubation of 0.5 ml heparinized human blood with the phagocytic stimulus of zymosan dose- and time-dependently(More)
1 Dept. of Immunology, Naval Medical Research Institute, Bethesda, MD 20014, USA 2 Washington Hospital Center, Washington DC, MD, USA 3 NRC Postdoctoral Research Associate on leave from the Dept. of Dermatology, University School of Medicine, Szeged, Hungary 4 Visiting fellow; permanent address: Dept. of Pulmonary Diseases, Division of Medicine, University(More)
R0ndinone et al. have recently reported that a high frequency of antinuclear and organ-specific antibodies are present in localized scleroderma [1]. Our results add to their findings. We found antinuclear antibodies (ANA) in a relatively high proport ion of patients with morphea and linear scleroderma. Clinical signs of systemic or organ-specific autoimmune(More)
We have observed the symptoms of systemic inflammatory response syndrome (SIRS) in male rats intoxicated by carbon tetrachloride (CCl(4)). Severe hypothermia, tachypnoea and increase in the heart beat min were diagnosed. These symptoms developed in the first hour of intoxication. The hepatic dysfunction was characterized by elevated bilirubin levels. In the(More)
WE have observed uncontrollable cardiogenic Tumour necrosis factorand shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) adenosine in endotoxin shockleading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration related cardiovascular symptoms of endotoxinaemia, and highly elevated plasma(More)
In vitro pre-incubation of monocytes derived from patients with Hodgkin's disease with tuftsin (50 µg/ml) significantly restored the deficient chemotactic responsiveness of these cells to the complement-derived factor C5a, as demonstrated by a monocyte migration assay based on the Boyden technique. Potentiation of the chemotactic responsiveness of monocytes(More)
 Neutral red is a vital stain known to be accumulated in the lysosomes of neutrophils and monocytes. It is used mainly to identify and detect the activated state of these cells. We have found that the extracellular application of physiological ceramide, i.e., a product of sphingomyelin hydrolysis and a newly defined intracellular second-messenger substance,(More)
Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-β2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-β2GPI peptide antibody. The rates of the(More)