Gy. Kövér

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This study examined the effects of adenosine on the renal function. In ten normal dogs intrarenal adenosine infusion (20 nmol/kg/min) increased the renal blood flow (RBF) from 521 +/- 20 ml/min to 582 +/- 23 ml/min. The extraction of PAH (EPAH) decreased from 0.85 +/- 0.02 to 0.79 +/- 0.02, the Einulin from 0.24 +/- 0.02 to 0.18 +/- 0.02. We conclude that(More)
The effects of furosemide on urine flow, sodium and potassium excretion and on plasma renin activity (PRA) were studied in anesthetized rabbits with and without pretreatment with indomethacin 5 mg/kg. Furosemide caused a 10-fold increase in urine flow and in sodium excretion, and a 2-3 fold increase in PRA. Pretreatment with the prostaglandin synthesis(More)
The renal effects of an acute extracellular fluid volume expansion (50 ml Ringer/kg body weight/60 min) were studied in aldosterone-treated (100 microgram/kg), anesthetized rabbits with and without pretreatment with either indomethacin (3.0 mg/kg) or diclofenac sodium (3.0 mg/kg), two different inhibitors of renal prostaglandin (PG) biosynthesis. In(More)
The effect of furosemide and indomethacin on renal function was investigated in anesthetized dogs. 1. On infusing 0.05 mg/kg/min furosemide directly into the left renal artery, about 18% of the filtered water and 19% of the filtered sodium was excreted in both non-hydrated and hydrated dogs. 2. Under the effect of 0.1 mg/kg/min indomethacin administered(More)
Studies were carried out in anaesthetized dogs, to determine the effects of volume expansion induced by Ringer's solution, plasma taken from non-hydrated or previously volume expanded animals on the natriuretic response of the kidney. When the animals were infused with Ringer's solution (0.25 ml/kg/min iv.) water and sodium excretion increased gradually(More)
The present study quantitated the effects of extracellular volume expansion on sodium and water excretion in 118 anesthetized dogs. The animals received a priming injection of 10 ml kg-1 Ringer solution i.v. which was followed by a constant Ringer solution infusion at a rate of 0.25 ml.min-1.kg-1 until the end of the experiment. Fifteen minutes after the(More)
To determine the prostaglandin dependent and independent effects of bradykinin in the kidney, bradykinin (0.05 microgram/min/kg body weight) was infused into the left renal artery during inhibition of prostaglandin synthesis by indomethacin. Indomethacin, 0.1 mg/min/kg body weight i.v. produced a marked fall in urine output and sodium excretion in(More)
Nach Infusion von 20 mg/min Papaverin während 10 min in die Arteria renalis nimmt die durch die Niere strömende Blutmenge zu. Beträchtlich erhöhen sich die Na-Ausscheidung und Diurese. Gleichzeitig kommt es zu einer starken Verminderung der PAH-Clearance und -Extraktion, sowie der Kreatinin-Clearance und -Extraktion. Die Vermehrung der Nierendurchblutung(More)
The effects of acute hypercalcemia on renal function were evaluated in anesthetized mongrel dogs. Calcium concentration was increased by infusion of CaCl2 solution into the left renal artery at two different rates. At the lower rate of infusion (0.010 mM/kg/min) the plasma total calcium concentration in the left kidney increased from 2.5 mM/l to 3.76 mM/l(More)