György Csordás

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Structural and functional features and significance of the physical linkage between ER and mitochondria

György Csordás, Christian Renken, +6 authors György Hajnóczky
The Journal of cell biology
2006

The role of mitochondria in cell metabolism and survival is controlled by calcium signals that are commonly transmitted at the close associations between mitochondria and endoplasmic reticulum (ER).… (More)

Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface.

György Csordás, Péter Várnai, +5 authors György Hajnóczky
Molecular cell
2010

The ER-mitochondrial junction provides a local calcium signaling domain that is critical for both matching energy production with demand and the control of apoptosis. Here, we visualize… (More)

MCUR1 is an Essential Component of Mitochondrial Ca2+ Uptake that Regulates Cellular Metabolism

Karthik Mallilankaraman, César R. Cárdenas, +14 authors Muniswamy Madesh
Nature Cell Biology
2012

Ca2+ flux across the mitochondrial inner membrane regulates bioenergetics, cytoplasmic Ca2+ signals and activation of cell death pathways. Mitochondrial Ca2+ uptake occurs at regions of close… (More)

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

György Csordás, Tünde Golenár, +11 authors György Hajnóczky
Cell metabolism
2013

Mitochondrial Ca(2+) uptake via the uniporter is central to cell metabolism, signaling, and survival. Recent studies identified MCU as the uniporter's likely pore and MICU1, an EF-hand protein, as… (More)

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria.

György Csordás, A. P. Thomas, György Hajnóczky
The EMBO journal
1999

Transmission of cytosolic [Ca2+] ([Ca2+]c) oscillations into the mitochondrial matrix is thought to be supported by local calcium control between IP3 receptor Ca2+ channels (IP3R) and mitochondria,… (More)

Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis.

György Hajnóczky, György Csordás, +4 authors Muqing Yi
Cell calcium
2006

Local Ca(2+) transfer between adjoining domains of the sarcoendoplasmic reticulum (ER/SR) and mitochondria allows ER/SR Ca(2+) release to activate mitochondrial Ca(2+) uptake and to evoke a matrix… (More)

SR/ER-mitochondrial local communication: calcium and ROS.

György Csordás, György Hajnóczky
Biochimica et biophysica acta
2009

Mitochondria form junctions with the sarco/endoplasmic reticulum (SR/ER), which support signal transduction and biosynthetic pathways and affect organellar distribution. Recently, these junctions… (More)

Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC).

György Báthori, György Csordás, Cecília García-Pérez, Erika Davies, György Hajnóczky
The Journal of biological chemistry
2006

Cell function depends on the distribution of cytosolic and mitochondrial factors across the outer mitochondrial membrane (OMM). Passage of metabolites through the OMM has been attributed to the… (More)

Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk.

Yun Chen, György Csordás, +10 authors Christoph Maack
Circulation research
2012

RATIONALE Mitochondrial Ca(2+) uptake is essential for the bioenergetic feedback response through stimulation of Krebs cycle dehydrogenases. Close association of mitochondria to the sarcoplasmic… (More)

Calcium signal transmission between ryanodine receptors and mitochondria.

Gabor Szalai, György Csordás, Basil M. Hantash, A. P. Thomas, György Hajnóczky
The Journal of biological chemistry
2000

Control of energy metabolism by increases of mitochondrial matrix [Ca(2+)] ([Ca(2+)](m)) may represent a fundamental mechanism to meet the ATP demand imposed by heart contractions, but the machinery… (More)

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