Gwendolyn S Carter

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Zygote arrest (Zar) proteins are crucial for early embryonic development, but their molecular mechanism of action is unknown. The Translational Control Sequence (TCS) in the 3' untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and translational activation in mature oocytes, but the protein(More)
5-Fluorouracil (5-Fu) is commonly used chemotherapy drug, but it can lead to the impairment of cognitive function. The pathogenesis of this injury is unknown but may involve modifications to dendritic structure and/or alterations in dendritic spine density and morphology. Dendritic spines are sites of excitatory synaptic transmission and changes in spine(More)
4726 Introduction. We evaluated the safety of I/M-E depots administered every two weeks, in hormone refractory prostate cancer patients receiving chemotherapy. Due to high incidence of thrombo-embolic (TE) events associated with oral estrogens, sensitive markers of coagulation activation were monitored during I/M-E treatments to guide initiation of(More)
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