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Sensory information reaches the cerebral cortex through the thalamus, which differentially relays this input depending on the state of arousal. Such 'gating' involves inhibition of the thalamocortical relay neurons by the reticular nucleus of the thalamus, but the underlying mechanisms are poorly understood. We reconstructed the thalamocortical circuit as(More)
Characterizing the responsiveness of thalamic neurons is crucial to understanding the flow of sensory information. Typically, thalamocortical neurons possess two distinct firing modes. At depolarized membrane potentials, thalamic cells fire single action potentials and faithfully relay synaptic inputs to the cortex. At hyperpolarized potentials, the(More)
We analyze neuron models in which the maximal conductances of membrane currents are slowly varying dynamic variables regulated by the intracellular calcium concentration. These models allow us to study possible activity-dependent effects arising from processes that maintain and modify membrane channels in real neurons. Regulated model neurons maintain a(More)
We review diierent applications of silicon conductance-based neuron models implemented on analog circuits. At the single-cell level, we describe a circuit in which conductances are programmed to simulate various Hodgkin–Huxley type models; integrated in a hardware/software system, they provide a simulation tool; an illustrative example is the simulation of(More)
This paper describes an original neural simulation platform designed as a tool for computational neuroscience. The system, based on artificial electronic neurons implemented in specific integrated circuits, computes in real-time and emulates in analogue mode the electrical activity of single neurons or small neural networks. Neurons are modelled using a(More)
In this paper, we present a library of analog operators used for the analog real-time computation of the Hodgkin-Huxley formalism. These operators make it possible to design a silicon (Si) neuron that is dynamically tunable, and that reproduces different kinds of neurons. We used an original method in neuromorphic engineering to characterize this Si neuron.(More)
This paper deals with the implementation of an analog electronic system capable of emulating and/or characterizing the electrical activity of biological neurons. We detail the main characteristics and performances of the system, and point out its litheness as an experimentation tool : • high level of modeling accuracy, validated by simple and hybrid(More)
Sensory relay structures in the spinal cord dorsal horn are now thought to be active processing structures that function before supraspinal sensory integration. Dorsal horn neurons directly receive nociceptive (pain) signals from the periphery, express a high degree of functional plasticity and are involved in long-term sensitization and chronic pain. We(More)
  • Grégoire Chevalier, Elsa Suberbielle, Céline Monnet, Valérie Duplan, Guillaume Martin-Blondel, Fanny Farrugia +3 others
  • 2011
Following infection of the central nervous system (CNS), the immune system is faced with the challenge of eliminating the pathogen without causing significant damage to neurons, which have limited capacities of renewal. In particular, it was thought that neurons were protected from direct attack by cytotoxic T lymphocytes (CTL) because they do not express(More)
The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood. To analyze the electrophysiological properties of neurons infected with BDV, we used cultures of neurons grown on multielectrode arrays, allowing a real-time monitoring of the electrical activity across the network(More)